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Issue 100, 2014
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Expanding the utility of flow hydrogenation – a robust protocol restricting hydrodehalogenation

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Abstract

A commonly observed limitation of conducting hydrogenations under flow chemistry conditions is hydrodehalogenation. In a bid to circumvent this limitation a series of hydrogenation catalysts were screened, with 5% Pt/C (sulfided) catalyst identified as an effective catalyst to selectively effect reductive aminations, nitro reduction, and alkene reductions in the presence of halogen atoms. Additionally the optimised protocol cleanly reduced imines in the presence of a furan moiety indicating potential amenability to other labile functionalities.

Graphical abstract: Expanding the utility of flow hydrogenation – a robust protocol restricting hydrodehalogenation

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Article information


Submitted
04 Sep 2014
Accepted
22 Oct 2014
First published
23 Oct 2014

RSC Adv., 2014,4, 56743-56748
Article type
Communication
Author version available

Expanding the utility of flow hydrogenation – a robust protocol restricting hydrodehalogenation

L. Hizartzidis, P. J. Cossar, M. J. Robertson, M. I. Simone, K. A. Young, A. McCluskey and C. P. Gordon, RSC Adv., 2014, 4, 56743
DOI: 10.1039/C4RA09605C

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