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Issue 71, 2014
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Synthesis and bioactivity of nobilamide B

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An alternative and facile solution/solid-phase approach is reported for the total synthesis of neuroactive peptide, nobilamide B. Z-Dhb was formed in solution via EDC/CuCl induced elimination. The solid-phase synthesis employed HBTU/Oxyma Pure™ coupling using Barlos resin. Synthetic nobilamide B was also found to be neuroactive in primary cultures of dorsal root ganglion (DRG) neurons.

Graphical abstract: Synthesis and bioactivity of nobilamide B

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Article information

09 Jul 2014
12 Aug 2014
First published
18 Aug 2014

RSC Adv., 2014,4, 37609-37612
Article type

Synthesis and bioactivity of nobilamide B

M. P. V. Jacinto, M. S. Flores, Z. Lin, G. P. Concepcion, E. W. Schmidt, S. Faulkner and A. J. L. Villaraza, RSC Adv., 2014, 4, 37609
DOI: 10.1039/C4RA06873D

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