Issue 60, 2014
From the journal:

RSC Advances

Inflammatory modulation of stem cells by Magnetic Resonance Imaging (MRI)-detectable nanoparticles†

Sezin Aday,‡ab   Jose Paiva,‡ab   Susana Sousa,b   Renata S. M. Gomes,c   Susana Pedreiro,d   Po-Wah So,e   Carolyn Ann Carr,f   Lowri Cochlin,g   Ana Catarina Gomes,b   Artur Paivad  and  Lino Ferreira*ab  

* Corresponding authors

a CNC – Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal

b Biocant, Biotechnology Innovation Center, Cantanhede, Portugal
E-mail: lino@biocant.pt

c King's BHF Centre of Excellence, Cardiovascular Proteomics, King's College London, London, UK

d Centro de Histocompatibilidade do Centro, Coimbra, Portugal

e Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK

f Cardiac Metabolism Research Group, Department of Physiology, Anatomy & Genetics, University of Oxford, UK

g PulseTeq Limited, Chobham, Surrey, UK

Abstract

In the current work, we labelled human hematopoietic stem cells with polymeric nanoparticles (NPs) that can be tracked by Magnetic Resonance Imaging (MRI) and studied their effect on cell metabolism, proliferation, secretomics, genomics and differentiation. We showed that NPs had no effect on the stem cell differentiation program but affected their paracrine activity.

Graphical abstract: Inflammatory modulation of stem cells by Magnetic Resonance Imaging (MRI)-detectable nanoparticles

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Article information

DOI
https://doi.org/10.1039/C4RA04041D
Article type
Communication
Submitted
02 May 2014
Accepted
02 Jul 2014
First published
02 Jul 2014

RSC Adv., 2014,4, 31706-31709

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Inflammatory modulation of stem cells by Magnetic Resonance Imaging (MRI)-detectable nanoparticles

S. Aday, J. Paiva, S. Sousa, R. S. M. Gomes, S. Pedreiro, P. So, C. A. Carr, L. Cochlin, A. C. Gomes, A. Paiva and L. Ferreira, RSC Adv., 2014, 4, 31706 DOI: 10.1039/C4RA04041D

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