Efficient construction of C–S and C–N bonds via metal-free reductive coupling of N-tosylhydrazones with benzo[d]thiazole-2-thiol

Abstract

An efficient procedure for the synthesis of diverse benzo[d]thiazole derivatives has been developed via metal-free reductive coupling of N-tosylhydrazones with benzo[d]thiazole-2-thiols. 2-Thio-substituted benzothiazoles are useful synthetic intermediates and promising biologically active compounds. The present process tolerates a wide range of substrates with high efficiency and moderate selectivity.