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Issue 6, 2014
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Solvent-free peptide synthesis assisted by microwave irradiation: environmentally benign synthesis of bioactive peptides

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Abstract

An efficient and facile, solvent-free peptide synthesis assisted by microwave irradiation, using DIC/HONB as the coupling reagent combination is reported. Key features of this original protocol are solvent-free synthesis, very short reaction time and scalability without affecting yield and purity. The versatility of the method was successfully demonstrated by synthesizing several biologically active peptides in high purity, yield and without racemization.

Graphical abstract: Solvent-free peptide synthesis assisted by microwave irradiation: environmentally benign synthesis of bioactive peptides

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Supplementary files

Publication details

The article was received on 13 Nov 2013, accepted on 25 Nov 2013 and first published on 02 Dec 2013


Article type: Communication
DOI: 10.1039/C3RA46643D
RSC Adv., 2014,4, 3065-3069

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    Solvent-free peptide synthesis assisted by microwave irradiation: environmentally benign synthesis of bioactive peptides

    A. Mahindra, N. Patel, N. Bagra and R. Jain, RSC Adv., 2014, 4, 3065
    DOI: 10.1039/C3RA46643D

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