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Issue 26, 2014
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Novel biodegradable heparin-coated nanocomposite system for targeted drug delivery

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Abstract

Bare (∼10 nm) and heparin (HP)-coated superparamagnetic iron oxide nanoparticles (SPIO NPs; 42 nm) were formulated by a co-precipitation technique. The bare and HP–SPIO NPs had saturation magnetization of 50–55 emu g−1 at 300 K. The anticancer drugs, doxorubicin (DOX) and paclitaxel (PTX), were separately partitioned in the SPIO core to compare their anti-neoplastic effects on the proliferation of A2780 and OVCAR-3 human ovarian cancer cells. The results revealed that the DOX–HP–SPIO NPs (85 nm) and PTX–HP–SPIO NPs (71 nm) showed sustained and pH-sensitive release of DOX (87%) and PTX (75%), respectively, at pH 6.0, even up to two weeks. Meanwhile, 10 μg ml−1 DOX–HP–SPIO NPs and PTX–HP–SPIO NP caused 95 and 84%, and 85 and 77% apoptosis in A2780 and OVCAR-3 cells, respectively, with a sharp decrease in the level of bcl-2 and survivin proteins and increased expression of proapoptotic proteins, like bax and NF-κB. So, the presently formulated nanocomposite-based drug delivery system was readily internalized into tumor cells and induced a higher apoptosis rate.

Graphical abstract: Novel biodegradable heparin-coated nanocomposite system for targeted drug delivery

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Publication details

The article was received on 28 Jul 2013, accepted on 22 Jan 2014 and first published on 27 Jan 2014


Article type: Paper
DOI: 10.1039/C3RA43967D
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RSC Adv., 2014,4, 13719-13728

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    Novel biodegradable heparin-coated nanocomposite system for targeted drug delivery

    A. Javid, S. Ahmadian, A. A. Saboury, S. M. Kalantar and S. Rezaei-Zarchi, RSC Adv., 2014, 4, 13719
    DOI: 10.1039/C3RA43967D

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