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Issue 1, 2014
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Benzoate dioxygenase from Ralstonia eutropha B9 – unusual regiochemistry of dihydroxylation permits rapid access to novel chirons

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Abstract

Oxidation of benzoic acid by a microorganism expressing benzoate dioxygenase leads to the formation of an unusual ipso, ortho arene cis-diol in sufficient quantities to be useful for synthesis. This homochiral diol possesses an array of differentiated functionality which can be exploited to access diverse highly oxygenated structures by concise synthetic sequences.

Graphical abstract: Benzoate dioxygenase from Ralstonia eutropha B9 – unusual regiochemistry of dihydroxylation permits rapid access to novel chirons

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Publication details

The article was received on 26 Nov 2013, accepted on 20 Dec 2013 and first published on 08 Jan 2014


Article type: Research Article
DOI: 10.1039/C3QO00057E
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Citation: Org. Chem. Front., 2014,1, 79-90
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    Benzoate dioxygenase from Ralstonia eutropha B9 – unusual regiochemistry of dihydroxylation permits rapid access to novel chirons

    J. A. Griffen, S. J. Kenwright, S. Abou-Shehada, S. Wharry, T. S. Moody and S. E. Lewis, Org. Chem. Front., 2014, 1, 79
    DOI: 10.1039/C3QO00057E

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