Issue 44, 2018

Accessing 4-oxy-substituted isoquinolinones via C–H activation and regioselective migratory insertion with electronically biased ynol ethers

Abstract

The rhodium-catalyzed C–H activation and annulation with ynol ethers to directly provide 4-oxy substituted isoquinolinones is reported. The polarized nature of ynol ethers provides an electronic bias for controlling the regioselectivity of the migratory insertion process. While the highly reactive nature of ynol ethers presents a challenge, mild conditions were found to provide product in moderate to good yield. Utility was demonstrated by application in the synthesis of a prolyl-4-hydroxylase inhibitor framework.

Graphical abstract: Accessing 4-oxy-substituted isoquinolinones via C–H activation and regioselective migratory insertion with electronically biased ynol ethers

Supplementary files

Article information

Article type
Paper
Submitted
08 Aug 2018
Accepted
24 Oct 2018
First published
24 Oct 2018

Org. Biomol. Chem., 2018,16, 8639-8646

Accessing 4-oxy-substituted isoquinolinones via C–H activation and regioselective migratory insertion with electronically biased ynol ethers

B. L. Coles-Taylor, M. S. McCallum, J. S. Lee and B. W. Michel, Org. Biomol. Chem., 2018, 16, 8639 DOI: 10.1039/C8OB02622J

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