Issue 22, 2016
From the journal:

Organic & Biomolecular Chemistry

Orthogonal dual-click diyne for CuAAC and/or SPAAC couplings†

Ron R. Ramsubhaga  and  Gregory B. Dudley*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida, USA
E-mail: gdudley@chem.fsu.edu

Abstract

Carbamate-tethered propargyl and benzocyclononyne moieties within a single molecular unit undergo cycloaddition with azides under complementary CuAAC and/or SPAAC coupling conditions. The carbamate linker can be cleaved by analogy to the –CBz protecting group for click capture-and-release applications.

Graphical abstract: Orthogonal dual-click diyne for CuAAC and/or SPAAC couplings

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Article information

DOI
https://doi.org/10.1039/C6OB00795C
Article type
Communication
Submitted
13 Apr 2016
Accepted
13 May 2016
First published
13 May 2016

Org. Biomol. Chem., 2016,14, 5028-5031

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Orthogonal dual-click diyne for CuAAC and/or SPAAC couplings

R. R. Ramsubhag and G. B. Dudley, Org. Biomol. Chem., 2016, 14, 5028 DOI: 10.1039/C6OB00795C

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