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Issue 22, 2016
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Orthogonal dual-click diyne for CuAAC and/or SPAAC couplings

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Abstract

Carbamate-tethered propargyl and benzocyclononyne moieties within a single molecular unit undergo cycloaddition with azides under complementary CuAAC and/or SPAAC coupling conditions. The carbamate linker can be cleaved by analogy to the –CBz protecting group for click capture-and-release applications.

Graphical abstract: Orthogonal dual-click diyne for CuAAC and/or SPAAC couplings

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Publication details

The article was received on 13 Apr 2016, accepted on 13 May 2016 and first published on 13 May 2016


Article type: Communication
DOI: 10.1039/C6OB00795C
Citation: Org. Biomol. Chem., 2016,14, 5028-5031
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    Orthogonal dual-click diyne for CuAAC and/or SPAAC couplings

    R. R. Ramsubhag and G. B. Dudley, Org. Biomol. Chem., 2016, 14, 5028
    DOI: 10.1039/C6OB00795C

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