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Issue 46, 2014
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Design strategies for bioorthogonal smart probes

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Bioorthogonal chemistry has enabled the selective labeling and detection of biomolecules in living systems. Bioorthogonal smart probes, which become fluorescent or deliver imaging or therapeutic agents upon reaction, allow for the visualization of biomolecules or targeted delivery even in the presence of excess unreacted probe. This review discusses the strategies used in the development of bioorthogonal smart probes and highlights the potential of these probes to further our understanding of biology.

Graphical abstract: Design strategies for bioorthogonal smart probes

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The article was received on 30 Jul 2014, accepted on 15 Sep 2014 and first published on 15 Oct 2014

Article type: Review Article
DOI: 10.1039/C4OB01632G
Org. Biomol. Chem., 2014,12, 9307-9320

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    Design strategies for bioorthogonal smart probes

    P. Shieh and C. R. Bertozzi, Org. Biomol. Chem., 2014, 12, 9307
    DOI: 10.1039/C4OB01632G

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