Jump to main content
Jump to site search

Issue 46, 2014
Previous Article Next Article

A review of methods to synthesise 4′-substituted nucleosides

Author affiliations

Abstract

Modified nucleosides have received a great deal of attention from the scientific community, either for use as therapeutic agents, diagnostic tools, or as molecular probes. Perhaps the most difficult position of a nucleoside to modify is the 4′-position. Chemists have developed innovative methods to achieve this in a stereoselective manner to allow incorporation of a variety of functional groups. This review provides a summary of the most commonly used or recently published methods for ribose, deoxy-ribose, 4′-thioribose, and carbocyclics.

Graphical abstract: A review of methods to synthesise 4′-substituted nucleosides

Back to tab navigation

Article information


Submitted
10 Jul 2014
Accepted
30 Sep 2014
First published
01 Oct 2014

Org. Biomol. Chem., 2014,12, 9291-9306
Article type
Review Article
Author version available

A review of methods to synthesise 4′-substituted nucleosides

M. Betson, N. Allanson and P. Wainwright, Org. Biomol. Chem., 2014, 12, 9291 DOI: 10.1039/C4OB01449A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements