Issue 30, 2014

Copper-catalyzed nucleophilic trifluoromethylation of benzylic chlorides

Abstract

Reactions of primary and secondary benzylic chlorides with trifluoromethyltrimethylsilane in the presence of a catalytic amount of copper(I) thiophene-2-carboxylate (CuTC) have been found to give the corresponding benzylic trifluoromethylated products in good to high yields.

Graphical abstract: Copper-catalyzed nucleophilic trifluoromethylation of benzylic chlorides

Supplementary files

Article information

Article type
Communication
Submitted
09 May 2014
Accepted
11 Jun 2014
First published
11 Jun 2014
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2014,12, 5594-5596

Author version available

Copper-catalyzed nucleophilic trifluoromethylation of benzylic chlorides

Y. Miyake, S. Ota, M. Shibata, K. Nakajima and Y. Nishibayashi, Org. Biomol. Chem., 2014, 12, 5594 DOI: 10.1039/C4OB00957F

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