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Abstract | Cited by

An efficient and practical method for the direct cross-coupling between quinolones and a range of azoles was developed via copper-mediated C–H functionalization. This synthetic strategy provides a convenient access to a variety of C3-heteroaryl quinolones, quinolinone, nalidixic acid, uracil, pyridone and chromone derivatives, which are prominent structural motifs in many biologically active compounds.

Graphical abstract: A copper-mediated cross-coupling approach for the synthesis of 3-heteroaryl quinolone and related analogues

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