Issue 29, 2014

Electrophilic sulfhydration of 8-nitro-cGMP involves sulfane sulfur

Abstract

The formation of 8-SH-cGMP from the reaction between hydrogen sulfide and 8-nitro-guanosine-3′,5′-cyclic monophosphate in the presence of thiols does not take place by nucleophilic attack of the hydrosulfide anion, as previously proposed, but first involves the formation of reactive species containing sulfane sulfur, like persulfides.

Graphical abstract: Electrophilic sulfhydration of 8-nitro-cGMP involves sulfane sulfur

Supplementary files

Article information

Article type
Communication
Submitted
28 Apr 2014
Accepted
11 Jun 2014
First published
12 Jun 2014

Org. Biomol. Chem., 2014,12, 5360-5364

Author version available

Electrophilic sulfhydration of 8-nitro-cGMP involves sulfane sulfur

V. Terzić, D. Padovani, V. Balland, I. Artaud and E. Galardon, Org. Biomol. Chem., 2014, 12, 5360 DOI: 10.1039/C4OB00868E

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