Unactivated yne-en-ynes reacted with a range of substituted aryl halides in the presence of Pd(OAc)2–PPh3 to afford diazaspiro[4.5]decane with exocyclic double bonds. Three carbon–carbon bonds are formed in this domino reaction, which involves highly regioselective C–C coupling and spiro scaffold steps.
![Graphical abstract: One-step synthesis of diazaspiro[4.5]decane scaffolds with exocyclic double bonds](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C4OB00516C&imageInfo.ImageIdentifier.Year=2014)
L. Li, Q. Hu, P. Zhou, H. Xie, X. Zhang, H. Zhang, Y. Hu, F. Yin and Y. Hu, Org. Biomol. Chem., 2014, 12, 5356 DOI: 10.1039/C4OB00516C
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