Issue 31, 2014

A facile route to 5-methyl-5H-indeno[1,2-c]quinolones via palladium-catalyzed cyclization of 2-alkynylbromobenzenes with N,N-dimethyl-2-alkynylanilines

Abstract

A tandem reaction catalyzed by palladium is developed to provide a facile and simple route for the synthesis of 5-methyl-5H-indeno[1,2-c]quinolones, which can introduce diversity and complexity into the products from readily available starting materials. This transformation proceeds well with good functional group tolerance.

Graphical abstract: A facile route to 5-methyl-5H-indeno[1,2-c]quinolones via palladium-catalyzed cyclization of 2-alkynylbromobenzenes with N,N-dimethyl-2-alkynylanilines

Supplementary files

Article information

Article type
Paper
Submitted
05 Apr 2014
Accepted
30 May 2014
First published
03 Jun 2014

Org. Biomol. Chem., 2014,12, 5861-5865

Author version available

A facile route to 5-methyl-5H-indeno[1,2-c]quinolones via palladium-catalyzed cyclization of 2-alkynylbromobenzenes with N,N-dimethyl-2-alkynylanilines

X. Pan, Y. Luo, Y. Kuang and G. Li, Org. Biomol. Chem., 2014, 12, 5861 DOI: 10.1039/C4OB00706A

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