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Issue 28, 2014
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Enantioselective one-pot synthesis of dihydroquinolones via BINOL-derived Lewis acid catalysis

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Abstract

A high-yielding and diastereoselective route to biologically significant 2-aryl- and 2-alkyl-3-amido dihydroquinolones has been developed in up to 90 : 10 e.r. by employing a novel Lewis acidic BINOL-derived copper(II) catalyst.

Graphical abstract: Enantioselective one-pot synthesis of dihydroquinolones via BINOL-derived Lewis acid catalysis

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Article information


Submitted
24 Mar 2014
Accepted
03 Jun 2014
First published
13 Jun 2014

Org. Biomol. Chem., 2014,12, 5094-5097
Article type
Communication
Author version available

Enantioselective one-pot synthesis of dihydroquinolones via BINOL-derived Lewis acid catalysis

P. C. Knipe and M. D. Smith, Org. Biomol. Chem., 2014, 12, 5094
DOI: 10.1039/C4OB00627E

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