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Two series of extremely useful 2-C-substituted benzothiazoles containing gem-bisphosphonates and aryl-substituted nitriles were synthesized here via a copper-promoted domino condensation/S-arylation/heterocyclization process.

Graphical abstract: Synthesis of 2-C-substituted benzothiazoles via a copper-promoted domino condensation/S-arylation/heterocyclization process

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