Issue 15, 2014
From the journal:

Organic & Biomolecular Chemistry

NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides†

So Won Youn,*a   Hyoung Sub Songa  and  Jong Hyub Parka  

* Corresponding authors

a Department of Chemistry and Research Institute for Natural Sciences, Hanyang University, Seoul 133-791, Korea
E-mail: sowony73@hanyang.ac.kr

Abstract

An efficient NHC-catalyzed domino oxidation/oxa-Michael addition reaction of 2-alkenylbenzaldehydes has been developed to afford 3-substituted phthalides bearing a C3-stereogenic center with a broad substrate scope and wide functional group tolerance. The preliminary results of the asymmetric process have been provided as well.

Graphical abstract: NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides

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Article information

DOI
https://doi.org/10.1039/C3OB42546K
Article type
Paper
Submitted
20 Dec 2013
Accepted
28 Jan 2014
First published
28 Jan 2014

Org. Biomol. Chem., 2014,12, 2388-2393

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NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides

S. W. Youn, H. S. Song and J. H. Park, Org. Biomol. Chem., 2014, 12, 2388 DOI: 10.1039/C3OB42546K

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