The intrinsic coagulation activity of silica nanoparticles strongly depends on their surface curvature. Nanoparticles with higher surface curvature do not denature blood coagulation factor XII on its surface, providing a coagulation ‘silent’ surface, while nanoparticles with lower surface curvature show denaturation and concomitant coagulation.
T. Kushida, K. Saha, C. Subramani, V. Nandwana and V. M. Rotello, Nanoscale, 2014, 6, 14484 DOI: 10.1039/C4NR04128C
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