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Issue 7, 2014
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Decreased serum zinc is an effect of ageing and not Alzheimer's disease

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Abstract

We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer's disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed.

Graphical abstract: Decreased serum zinc is an effect of ageing and not Alzheimer's disease

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Publication details

The article was received on 05 Mar 2014, accepted on 19 Mar 2014 and first published on 20 Mar 2014


Article type: Communication
DOI: 10.1039/C4MT00060A
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Citation: Metallomics, 2014,6, 1216-1219
  • Open access: Creative Commons BY license
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    Decreased serum zinc is an effect of ageing and not Alzheimer's disease

    A. Rembach, D. J. Hare, J. D. Doecke, S. C. Burnham, I. Volitakis, C. J. Fowler, R. A. Cherny, C. McLean, R. Grimm, R. Martins, D. Ames, C. L. Masters, A. I. Bush and B. R. Roberts, Metallomics, 2014, 6, 1216
    DOI: 10.1039/C4MT00060A

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