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Issue 8, 2014
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Carbohydrate antigen delivery by water soluble copolymers as potential anti-cancer vaccines

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Abstract

Tumor associated carbohydrate antigens (TACAs) are overexpressed on tumor cells, which renders them attractive targets for anti-cancer vaccines. To overcome the poor immunogenicity of TACAs, we designed a polymer platform for antigen presentation by co-delivering TACA and helper T (Th) cell epitope on the same chain. The block copolymer was synthesized by cyanoxyl-mediated free radical polymerization followed by conjugation with a TACA Tn antigen and a mouse Th-cell peptide epitope derived from polio virus (PV) to afford the vaccine construct. The glycopolymer vaccine elicited an anti-Tn immune response with significant titers of IgG antibodies, which recognized Tn-expressing tumor cells.

Graphical abstract: Carbohydrate antigen delivery by water soluble copolymers as potential anti-cancer vaccines

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Supplementary files

Article information


Submitted
06 Mar 2014
Accepted
15 May 2014
First published
16 May 2014

Med. Chem. Commun., 2014,5, 1126-1129
Article type
Concise Article

Carbohydrate antigen delivery by water soluble copolymers as potential anti-cancer vaccines

Q. Qin, Z. Yin, P. Bentley and X. Huang, Med. Chem. Commun., 2014, 5, 1126
DOI: 10.1039/C4MD00103F

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