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Issue 4, 2014
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Effect of the 4′-substituted phenylalanine moiety of sansalvamide A peptide on antitumor activity

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Abstract

Eight sansalvamide A peptide analogues with 4′-fluoride, 4′-chloride, 4′-bromide, 4′-iodide, and 4′-methoxyphenylalanine moieties were synthesized. The effect of these para-substitutions of sansalvamide A peptide on their cytotoxicity was evaluated using HCT-116, MDA-MB-231, HT-29, HCT-15, K562, HeLa, and A549 cell lines. The 4′-methoxyphenylalanine analog of sansalvamide A peptide was found to be a promising antitumor agent.

Graphical abstract: Effect of the 4′-substituted phenylalanine moiety of sansalvamide A peptide on antitumor activity

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Supplementary files

Article information


Submitted
04 Oct 2013
Accepted
20 Dec 2013
First published
11 Feb 2014

Med. Chem. Commun., 2014,5, 463-467
Article type
Concise Article

Effect of the 4′-substituted phenylalanine moiety of sansalvamide A peptide on antitumor activity

S. Liu, Y. Yang, C. Zhao, J. Huang, C. Han and J. Han, Med. Chem. Commun., 2014, 5, 463
DOI: 10.1039/C3MD00294B

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