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Issue 10, 2014
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Oolong, black and pu-erh tea suppresses adiposity in mice via activation of AMP-activated protein kinase

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Abstract

It is well known that tea has a variety of beneficial impacts on human health, including anti-obesity effects. It is well documented that green tea and its constituent catechins suppress obesity, but the effects of other types of tea on obesity and the potential mechanisms involved are not yet fully understood. In this study, we investigated the suppression of adiposity by oolong, black and pu-erh tea and characterized the underlying molecular mechanism in vivo. We found that the consumption of oolong, black or pu-erh tea for a period of one week significantly decreased visceral fat without affecting body weight in male ICR mice. On a mechanistic level, the consumption of tea enhanced the phosphorylation of AMP-activated protein kinase (AMPK) in white adipose tissue (WAT). This was accompanied by the induction of WAT protein levels of uncoupling protein 1 and insulin-like growth factor binding protein 1. Our results indicate that oolong, black and pu-erh tea, and in particular, black tea, suppresses adiposity via phosphorylation of the key metabolic regulator AMPK and increases browning of WAT.

Graphical abstract: Oolong, black and pu-erh tea suppresses adiposity in mice via activation of AMP-activated protein kinase

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Publication details

The article was received on 10 Feb 2014, accepted on 21 Jul 2014 and first published on 21 Jul 2014


Article type: Paper
DOI: 10.1039/C4FO00095A
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Food Funct., 2014,5, 2420-2429

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    Oolong, black and pu-erh tea suppresses adiposity in mice via activation of AMP-activated protein kinase

    Y. Yamashita, L. Wang, L. Wang, Y. Tanaka, T. Zhang and H. Ashida, Food Funct., 2014, 5, 2420
    DOI: 10.1039/C4FO00095A

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