Jump to main content
Jump to site search

Issue 81, 2016
Previous Article Next Article

A robust and quantitative assay platform for multiplexed, high throughput screening of protein kinase inhibitors

Author affiliations

Abstract

We present a new platform for multiplexed protein kinase activity assay using TiO2 decorated graphene oxide (GO), which is applicable to high throughput inhibitor screening. On the basis of the strong affinity of TiO2 for the phosphate group and the fluorescence quenching capability of GO, phosphorylation of substrates by protein kinases was quantitatively measured in a short time.

Graphical abstract: A robust and quantitative assay platform for multiplexed, high throughput screening of protein kinase inhibitors

Back to tab navigation

Supplementary files

Article information


Submitted
15 Jul 2016
Accepted
08 Sep 2016
First published
08 Sep 2016

Chem. Commun., 2016,52, 12112-12115
Article type
Communication

A robust and quantitative assay platform for multiplexed, high throughput screening of protein kinase inhibitors

J. Lee, I. Park, G. Park, K. Cho, H. Park and D. Min, Chem. Commun., 2016, 52, 12112
DOI: 10.1039/C6CC05834E

Social activity

Search articles by author

Spotlight

Advertisements