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Issue 95, 2014
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Practical preparation of challenging amides from non-nucleophilic amines and esters under flow conditions

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Abstract

A fast and efficient protocol for the formation of amides from low nucleophilic amines and esters in flow is described. Products were obtained in good to excellent yields and with the advantage of simultaneous mixing of all reagents at once, avoiding steps for intermediate formation. The protocol is also suitable to be combined with ester synthesis, resulting in the preparation of amides in-line from haloarenes.

Graphical abstract: Practical preparation of challenging amides from non-nucleophilic amines and esters under flow conditions

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Supplementary files

Article information


Submitted
10 Sep 2014
Accepted
09 Oct 2014
First published
09 Oct 2014

Chem. Commun., 2014,50, 15094-15097
Article type
Communication
Author version available

Practical preparation of challenging amides from non-nucleophilic amines and esters under flow conditions

J. L. Vrijdag, F. Delgado, N. Alonso, W. M. De Borggraeve, N. Pérez-Macias and J. Alcázar, Chem. Commun., 2014, 50, 15094
DOI: 10.1039/C4CC07129H

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