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Issue 51, 2014
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Pd-catalyzed highly regio-, diastereo-, and enantioselective allylic alkylation of α-fluorophosphonates

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Abstract

Highly efficient Pd-catalyzed asymmetric allylic alkylation reaction of ethyl-2-fluoro-2-(diethoxyphosphoryl)acetate with monosubstituted allylic substrates has been developed, affording corresponding α-fluorophosphonates with two chiral centers in high regio-, diastereo- and enantio-selectivities. The usefulness of the products in organic synthesis has been demonstrated.

Graphical abstract: Pd-catalyzed highly regio-, diastereo-, and enantioselective allylic alkylation of α-fluorophosphonates

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Publication details

The article was received on 24 Mar 2014, accepted on 04 May 2014 and first published on 06 May 2014


Article type: Communication
DOI: 10.1039/C4CC02158D
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Chem. Commun., 2014,50, 6751-6753

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    Pd-catalyzed highly regio-, diastereo-, and enantioselective allylic alkylation of α-fluorophosphonates

    Y. Huang, Q. Zhang, P. Fang, T. Chen, J. Zhu and X. Hou, Chem. Commun., 2014, 50, 6751
    DOI: 10.1039/C4CC02158D

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