Direct monomethylation of primary amines with methyl triflate was achieved with high selectivity (up to 96%). The key point of this single methyl transfer stems from the use of HFIP as the solvent that interferes with amines and avoids overmethylation.
T. Lebleu, X. Ma, J. Maddaluno and J. Legros, Chem. Commun., 2014, 50, 1836 DOI: 10.1039/C3CC48997C
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