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Issue 25, 2014
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Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies

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Abstract

Biomimetic nanoparticles prepared by self-assembly of iminosugar-based glycopolypeptides evidenced remarkable multivalency properties when inhibiting α-mannosidase activity. This approach paves the way to obtain biologically active drug delivery systems having glycosidase inhibition potency.

Graphical abstract: Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies

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Article information


Submitted
25 Oct 2013
Accepted
07 Feb 2014
First published
07 Feb 2014

Chem. Commun., 2014,50, 3350-3352
Article type
Communication
Author version available

Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies

C. Bonduelle, J. Huang, T. Mena-Barragán, C. Ortiz Mellet, C. Decroocq, E. Etamé, A. Heise, P. Compain and S. Lecommandoux, Chem. Commun., 2014, 50, 3350
DOI: 10.1039/C3CC48190E

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