Jump to main content
Jump to site search

Issue 10, 2014
Previous Article Next Article

Thixotropic silk nanofibril-based hydrogel with extracellular matrix-like structure

Author affiliations

Abstract

Silk fibroin (SF) based materials have been widely studied and applied in bio-related areas due to their excellent structural and biological properties. Here, we present an injectable hydrogel formed by SF nanofibrils via simple fibrillation and centrifugation approach. The hydrogels with extracellular matrix-like structure not only perform the sufficient mechanical properties, but also show outstanding thixotropic character, whose storage modulus (G′) can recover to 93% within 40 seconds after a large shearing strain (5000 %). More importantly, the injectable hydrogel exhibits significant biocompatibility for L929 cells cultured in hydrogel after injection, illustrated by cell viability and cytotoxicity assays. All of these results indicate that such SF nanofibril-based hydrogel has promise in application such as a cell therapy carrier.

Graphical abstract: Thixotropic silk nanofibril-based hydrogel with extracellular matrix-like structure

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Jun 2014, accepted on 12 Jul 2014 and first published on 31 Jul 2014


Article type: Communication
DOI: 10.1039/C4BM00214H
Author version
available:
Download author version (PDF)
Biomater. Sci., 2014,2, 1338-1342

  •   Request permissions

    Thixotropic silk nanofibril-based hydrogel with extracellular matrix-like structure

    Y. Liu, S. Ling, S. Wang, X. Chen and Z. Shao, Biomater. Sci., 2014, 2, 1338
    DOI: 10.1039/C4BM00214H

Search articles by author

Spotlight

Advertisements