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Issue 33, 2014
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Iodonium ylides for one-step, no-carrier-added radiofluorination of electron rich arenes, exemplified with 4-(([18F]fluorophenoxy)-phenylmethyl)piperidine NET and SERT ligands

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Abstract

Iodonium ylide precursors of electron rich arenes, i.e. the NET and SERT ligands 4-((3- and 4-fluorophenoxy)phenylmethyl)piperidine, served as model compounds for the direct substitution with n.c.a. [18F]fluoride. Good radiochemical yields of about 20% were obtained in reaction times of ca. 130 minutes with a molar activity of the labelled ligands of more than 50 GBq μmol−1. Those failed as in vivo probes in first evaluation studies. Several important insights, however, were gained into the reaction of ylides, e.g. an unexpected formation of regioisomers. The results clearly demonstrate that aryliodonium ylides are a promising alternative to the well-known diaryliodonium salts for the direct preparation of complex, electron rich n.c.a. [18F]fluoroarenes.

Graphical abstract: Iodonium ylides for one-step, no-carrier-added radiofluorination of electron rich arenes, exemplified with 4-(([18F]fluorophenoxy)-phenylmethyl)piperidine NET and SERT ligands

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Publication details

The article was received on 23 Jan 2014, accepted on 27 Mar 2014 and first published on 28 Mar 2014


Article type: Paper
DOI: 10.1039/C4RA00674G
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RSC Adv., 2014,4, 17293-17299

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    Iodonium ylides for one-step, no-carrier-added radiofluorination of electron rich arenes, exemplified with 4-(([18F]fluorophenoxy)-phenylmethyl)piperidine NET and SERT ligands

    J. Cardinale, J. Ermert, S. Humpert and H. H. Coenen, RSC Adv., 2014, 4, 17293
    DOI: 10.1039/C4RA00674G

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