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Issue 8, 2014

Conjugated polymer nanoparticles for photoacoustic vascular imaging

Author affiliations

Abstract

Photoacoustic (PA) imaging is an emerging technique in biological imaging, which is able to provide high resolution and deep penetration depth. Exogenous contrast agents with strong near infrared (NIR) absorbance are highly desirable for PA imaging. In this work, we synthesized a conjugated polymer, poly[9,9-bis(4-(2-ethylhexyl)phenyl)fluorene-alt-co-6,7-bis(4-(hexyloxy)phenyl)-4,9-di(thiophen-2-yl)-thiadiazoloquinoxaline] (PFTTQ) by Suzuki polymerization, which shows strong absorption in the NIR range. The processability of PFTTQ allowed for its encapsulation into a 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2000) matrix to yield PFTTQ loaded DSPE-PEG2000 NPs (PFTTQ NPs) that are dispersible in water. As a result of their strong NIR absorbance and high non-radiative quantum yield (1 − fluorescence quantum yield), PFTTQ NPs show a strong ability to generate a PA signal. In addition, PFTTQ NPs show much higher photostability in comparison with Au NRs upon high energy pulse laser illumination at a fixed laser fluence of 15 mJ cm−2. The potential of PFTTQ NPs as a PA probe was further demonstrated using brain vascular imaging as an example.

Graphical abstract: Conjugated polymer nanoparticles for photoacoustic vascular imaging

Supplementary files

Article information


Submitted
11 Nov 2013
Accepted
19 Dec 2013
First published
20 Dec 2013

Polym. Chem., 2014,5, 2854-2862
Article type
Paper

Conjugated polymer nanoparticles for photoacoustic vascular imaging

J. Liu, J. Geng, L. Liao, N. Thakor, X. Gao and B. Liu, Polym. Chem., 2014, 5, 2854 DOI: 10.1039/C3PY01587D

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