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Issue 27, 2014
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Mechanistic studies for tri-targeted inhibition of enzymes involved in cholesterol biosynthesis by green tea polyphenols

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Abstract

In the present study, we found that three enzymes, MVK, MDD and FPPS, in the mevalonate pathway (MVP) of cholesterol biosynthesis, can be simultaneously inhibited by two green tea polyphenols ((−)-epicatechin-3-gallate, ECG; (−)-epigallocatechin-3-gallate, EGCG). Molecular dynamics simulations and pharmacophore studies were carried out to elucidate the tri-targeted inhibition mechanisms. Our results indicate that similar triangular binding pockets exist in all three enzymes, which is essential for their binding with polyphenols. Two distinct binding poses for ECG and EGCG were observed in our MD simulations. These results shed light on the potential for further selective and multi-targeted inhibitor design for the treatment of hyperlipidemia.

Graphical abstract: Mechanistic studies for tri-targeted inhibition of enzymes involved in cholesterol biosynthesis by green tea polyphenols

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The article was received on 19 Mar 2014, accepted on 17 Apr 2014 and first published on 17 Apr 2014


Article type: Paper
DOI: 10.1039/C4OB00589A
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Org. Biomol. Chem., 2014,12, 4941-4951

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    Mechanistic studies for tri-targeted inhibition of enzymes involved in cholesterol biosynthesis by green tea polyphenols

    H. Ge, J. Liu, W. Zhao, Y. Wang, Q. He, R. Wu, D. Li and J. Xu, Org. Biomol. Chem., 2014, 12, 4941
    DOI: 10.1039/C4OB00589A

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