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Issue 48, 2014
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1-Trifluoromethylated isoquinolines via radical trifluoromethylation of isonitriles

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Abstract

A simple and efficient approach to biologically important 1-trifluoromethylated isoquinolines starting with readily prepared β-aryl-α-isocyano-acrylates and the commercially available Togni reagent as the CF3 radical precursor is described. These transformations occur in the absence of any transition metals and the title compounds are obtained in moderate to excellent yields. This protocol comprises a trifluoromethylation with concomitant isoquinoline framework construction.

Graphical abstract: 1-Trifluoromethylated isoquinolines via radical trifluoromethylation of isonitriles

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Supplementary files

Article information


Submitted
08 Oct 2014
Accepted
10 Oct 2014
First published
10 Oct 2014

Org. Biomol. Chem., 2014,12, 9895-9898
Article type
Paper
Author version available

1-Trifluoromethylated isoquinolines via radical trifluoromethylation of isonitriles

B. Zhang and A. Studer, Org. Biomol. Chem., 2014, 12, 9895 DOI: 10.1039/C4OB02145B

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