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Issue 5, 2014
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CuI-catalyzed cycloisomerization of propargyl amides

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Abstract

The synthesis of substituted dihydrooxazoles by the CuI-catalyzed cycloisomerization of terminal propargyl amides is reported. The reaction has been shown to have good substrate scope and experiments to delineate the mechanism have been performed. Substrates containing a benzylic methylene were oxidized to the ketone under the reaction conditions.

Graphical abstract: CuI-catalyzed cycloisomerization of propargyl amides

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Supplementary files

Article information


Submitted
10 Oct 2013
Accepted
29 Nov 2013
First published
02 Dec 2013

Org. Biomol. Chem., 2014,12, 795-800
Article type
Paper
Author version available

CuI-catalyzed cycloisomerization of propargyl amides

A. Alhalib and W. J. Moran, Org. Biomol. Chem., 2014, 12, 795
DOI: 10.1039/C3OB42030B

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