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Issue 7, 2014
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Decreased serum zinc is an effect of ageing and not Alzheimer's disease

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Abstract

We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer's disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed.

Graphical abstract: Decreased serum zinc is an effect of ageing and not Alzheimer's disease

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Supplementary files

Article information


Submitted
05 Mar 2014
Accepted
19 Mar 2014
First published
20 Mar 2014

This article is Open Access

Metallomics, 2014,6, 1216-1219
Article type
Communication
Author version available

Decreased serum zinc is an effect of ageing and not Alzheimer's disease

A. Rembach, D. J. Hare, J. D. Doecke, S. C. Burnham, I. Volitakis, C. J. Fowler, R. A. Cherny, C. McLean, R. Grimm, R. Martins, D. Ames, C. L. Masters, A. I. Bush and B. R. Roberts, Metallomics, 2014, 6, 1216
DOI: 10.1039/C4MT00060A

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