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Issue 3, 2014
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Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation

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Abstract

Biosynthesis of retinoic acid from retinaldehyde (retinal) is catalysed by an aldehyde dehydrogenase (ALDH) and its oxidation by cytochrome P450 enzymes (CYPs). Herein we show by phylogenetic analysis that the ALDHs and CYPs in the retinoic acid pathway in animals are much closer in evolutionary terms to cyanobacterial orthologs than would be expected from the standard models of evolution.

Graphical abstract: Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation

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Publication details

The article was received on 04 Oct 2013, accepted on 03 Jan 2014 and first published on 06 Jan 2014


Article type: Communication
DOI: 10.1039/C3MB70447E
Mol. BioSyst., 2014,10, 380-383

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    Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation

    A. Millard, D. J. Scanlan, C. Gallagher, A. Marsh and P. C. Taylor, Mol. BioSyst., 2014, 10, 380
    DOI: 10.1039/C3MB70447E

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