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Issue 8, 2014
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Synthesis of metal–organic frameworks by continuous flow

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A continuous flow process for the synthesis of a metal–organic framework using only water as the reaction medium and requiring only short residence times is described. This affords a new route to scale-up of materials incorporating many of the principles of Green Chemistry. The process is demonstrated by the synthesis MIL-53(Al) via continuous flow reaction requiring only 5–6 minutes with a space time yield of 1300 kg m−3 d−1. We have demonstrated the synthesis of 500 g of MIL-53(Al) using this process, which can be scaled-up further by simply feeding further solutions of metal salt and ligand through the reactor. The product has a higher surface area and a better colour than a commercially produced sample of this MOF. In addition, a new and effective method for the extraction of terephthalic acid from within the pores of MIL-53(Al) using supercritical ethanol has been developed, representing a new methodology for activation and removal of substrates from porous hosts.

Graphical abstract: Synthesis of metal–organic frameworks by continuous flow

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Article information

21 Feb 2014
21 May 2014
First published
06 Jun 2014

Green Chem., 2014,16, 3796-3802
Article type
Author version available

Synthesis of metal–organic frameworks by continuous flow

P. A. Bayliss, I. A. Ibarra, E. Pérez, S. Yang, C. C. Tang, M. Poliakoff and M. Schröder, Green Chem., 2014, 16, 3796
DOI: 10.1039/C4GC00313F

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