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Issue 93, 2014
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Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative

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Abstract

A tetra-ortho-chloro substituted azobenzene unit was incorporated into a photoswitchable tethered ligand for ionotropic glutamate receptors. This compound confers the modified protein with the unusual optical responses of the substituted azo scaffold permitting channel opening with yellow and red light and channel closing with blue light.

Graphical abstract: Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative

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Supplementary files

Article information


Submitted
22 Aug 2014
Accepted
06 Oct 2014
First published
06 Oct 2014

This article is Open Access

Chem. Commun., 2014,50, 14613-14615
Article type
Communication
Author version available

Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative

A. Rullo, A. Reiner, A. Reiter, D. Trauner, E. Y. Isacoff and G. A. Woolley, Chem. Commun., 2014, 50, 14613
DOI: 10.1039/C4CC06612J

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