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Issue 84, 2014
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Continuous synthesis of artemisinin-derived medicines

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Abstract

Described is a continuous, divergent synthesis system which is coupled to continuous purification and is capable of producing four anti-malarial APIs. The system is comprised of three linked reaction modules for photooxidation/cyclization, reduction, and derivatization. A fourth module couples the crude reaction stream with continuous purification to yield pure API.

Graphical abstract: Continuous synthesis of artemisinin-derived medicines

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Article information


Submitted
03 Jul 2014
Accepted
29 Aug 2014
First published
29 Aug 2014

This article is Open Access

Chem. Commun., 2014,50, 12652-12655
Article type
Communication
Author version available

Continuous synthesis of artemisinin-derived medicines

K. Gilmore, D. Kopetzki, J. W. Lee, Z. Horváth, D. T. McQuade, A. Seidel-Morgenstern and P. H. Seeberger, Chem. Commun., 2014, 50, 12652
DOI: 10.1039/C4CC05098C

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