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Issue 22, 2014
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Applications of biocatalytic arene ipso,ortho cis-dihydroxylation in synthesis

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Abstract

The dearomatising dihydroxylation of aromatic molecules mediated by arene dioxygenase enzymes can provide cyclohexadiene-diols that are versatile starting materials for organic synthesis. Whereas oxidation of a substituted arene to give its ortho,meta-dihydrodiol has been demonstrated for numerous substrates and dioxygenases, formation of ipso,ortho-dihydrodiols has historically been underutilised in comparison. This feature article presents a chronological account of reported uses of such diols.

Graphical abstract: Applications of biocatalytic arene ipso,ortho cis-dihydroxylation in synthesis

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Article information


Submitted
21 Dec 2013
Accepted
05 Feb 2014
First published
11 Feb 2014

Chem. Commun., 2014,50, 2821-2830
Article type
Feature Article
Author version available

Applications of biocatalytic arene ipso,ortho cis-dihydroxylation in synthesis

S. E. Lewis, Chem. Commun., 2014, 50, 2821
DOI: 10.1039/C3CC49694E

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