An efficient method for N-arylation of purines is reported. The N-arylation is catalysed by Cu(I) and 4,7-bis(2-hydroxyethylamino)-1,10-phenanthroline (BHPhen) in aqueous DMF or ethanol. The reaction generally proceeds with high selectivity for the N9-position.
A. F. Larsen and T. Ulven, Chem. Commun., 2014, 50, 4997 DOI: 10.1039/C3CC48642G
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