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Issue 21, 2014
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Femtogram detection of cytokines in a direct dot-blot assay using SERS microspectroscopy and hydrophilically stabilized Au–Ag nanoshells

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Abstract

Rapid parallel detection of two cytokines (IL-6 and IL-8) with femtogram sensitivity in a simple direct dot-blot assay is demonstrated. The microspectroscopic SERS acquisition scheme employs rationally designed, hydrophilically stabilized Au–Ag nanoshells as SERS labels, which are optimized for signal enhancement upon red laser excitation.

Graphical abstract: Femtogram detection of cytokines in a direct dot-blot assay using SERS microspectroscopy and hydrophilically stabilized Au–Ag nanoshells

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Supplementary files

Article information


Submitted
12 Nov 2013
Accepted
14 Dec 2013
First published
16 Dec 2013

Chem. Commun., 2014,50, 2711-2714
Article type
Communication
Author version available

Femtogram detection of cytokines in a direct dot-blot assay using SERS microspectroscopy and hydrophilically stabilized Au–Ag nanoshells

Y. Wang, M. Salehi, M. Schütz and S. Schlücker, Chem. Commun., 2014, 50, 2711
DOI: 10.1039/C3CC48633H

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