Issue 32, 2013
From the journal:

Journal of Materials Chemistry B

In vitro controlled release of theophylline from metal–drug complexes†

Hao Wang,a   Tong-Liang Hu,*a   Rong-Mei Wen,a   Qian Wangb  and  Xian-He Bu*a  

* Corresponding authors

a Department of Chemistry, TKL of Metal and Molecule-Based Material Chemistry, and Synergetic Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China
E-mail: tlhu@nankai.edu.cn, buxh@nankai.edu.cn
Fax: +86-22-23502458

b Tianjin Institute of Pharmaceutical Sciences, Tianjin 300020, China

Abstract

Two new metal–drug complexes constructed from non-toxic zinc and theophylline (TPL), an anti-asthmatic active drug, have been introduced into a release system based on matrices of hydroxypropylmethylcellulose (HPMC) and microcrystalline cellulose (MC). The release rate of TPL from the metal–drug complexes could be controlled by the amount of MC added, and the release mechanism changed from anomalous transport to Fickian diffusion.

Graphical abstract: In vitro controlled release of theophylline from metal–drug complexes

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Article information

DOI
https://doi.org/10.1039/C3TB20633E
Article type
Communication
Submitted
02 May 2013
Accepted
26 Jun 2013
First published
27 Jun 2013

J. Mater. Chem. B, 2013,1, 3879-3882

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In vitro controlled release of theophylline from metal–drug complexes

H. Wang, T. Hu, R. Wen, Q. Wang and X. Bu, J. Mater. Chem. B, 2013, 1, 3879 DOI: 10.1039/C3TB20633E

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