Issue 32, 2013
From the journal:

Journal of Materials Chemistry B

Tunable self-assembled nanogels composed of well-defined thermoresponsive hyaluronic acid–polymer conjugates†

Jing Jing,ab   David Alaimo,c   Elly De Vlieghere,d   Christine Jérôme,c   Olivier De Wever,d   Bruno G. De Geest*e  and  Rachel Auzély-Velty*ab  

* Corresponding authors

a Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), Grenoble, France
E-mail: Rachel.auzely@cermav.cnrs.fr

b Université de Grenoble, Grenoble, France

c Center for Education and Research on Macromolecules (CERM), University of Liège, Liège, Belgium

d Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University, Ghent, Belgium

e Department of Pharmaceutics, Ghent University, Ghent, Belgium
E-mail: br.degeest@ugent.be

Abstract

Here we report that grafting temperature-responsive polymers onto hyaluronic acid allows temperature-induced self-assembly into nanogels with tunable size. These nanogels can be easily loaded with hydrophobic molecules and hold potential for anti-cancer drug delivery towards human ovarian cancer cells.

Graphical abstract: Tunable self-assembled nanogels composed of well-defined thermoresponsive hyaluronic acid–polymer conjugates

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Article information

DOI
https://doi.org/10.1039/C3TB20283F
Article type
Communication
Submitted
28 Feb 2013
Accepted
19 Jun 2013
First published
19 Jun 2013

J. Mater. Chem. B, 2013,1, 3883-3887

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Tunable self-assembled nanogels composed of well-defined thermoresponsive hyaluronic acid–polymer conjugates

J. Jing, D. Alaimo, E. De Vlieghere, C. Jérôme, O. De Wever, B. G. De Geest and R. Auzély-Velty, J. Mater. Chem. B, 2013, 1, 3883 DOI: 10.1039/C3TB20283F

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