A facile, regioselective and controllable bromination of aromatic amines using a CuBr2/Oxone® system

Xin-Le Li; Wei Wu; Xin-Heng Fan; Lian-Ming Yang

doi:10.1039/C3RA41664J

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A facile, regioselective and controllable bromination of aromatic amines using a CuBr₂/Oxone^® system†

Xin-Le Li,^ab Wei Wu,^ab Xin-Heng Fan^b and Lian-Ming Yang*^b

Author affiliations

* Corresponding authors

^a Beijing National Laboratory for Molecular Sciences (BNLMS), Laboratory of New Materials, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China

^b Graduate School of Chinese Academy of Sciences, Beijing 100049, P. R. China
E-mail: yanglm@iccas.ac.cn
Fax: +86-10-62559373
Tel: +86-10-62565609

Abstract

A combination of cupric bromide and Oxone^® serves as a facile, mild and effective reagent for the bromination of aromatic amines. Primary, secondary and tertiary aromatic amines are all suitable substrates. The reaction possesses high regioselectivity and functional group tolerance, and mono- and multi-brominated products can be obtained controllably in moderate to excellent yields.

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Article information

DOI: https://doi.org/10.1039/C3RA41664J
Article type: Communication
Submitted: 07 Apr 2013
Accepted: 29 May 2013
First published: 30 May 2013

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RSC Adv., 2013,3, 12091-12095

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A facile, regioselective and controllable bromination of aromatic amines using a CuBr₂/Oxone^® system

X. Li, W. Wu, X. Fan and L. Yang, RSC Adv., 2013, 3, 12091 DOI: 10.1039/C3RA41664J

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