Issue 6, 2014

A combined solid- and solution-phase approach provides convenient access to analogues of the calcium-dependent lipopeptide antibiotics

Abstract

The calcium-dependent lipopeptide antibiotics represent a promising new class of antimicrobials for use in combating drug-resistant bacteria. At present, daptomycin is the only such lipopeptide used clinically and displays potent antimicrobial activity against a number of pathogenic Gram-positive bacteria. Given the increasing need for new antibiotics, practical synthetic access to unnatural analogues of daptomycin and related antimicrobial lipopeptides is of value. We here report an efficient synthetic route combining solid- and solution-phase techniques that allows for the rapid preparation of daptomycin analogues. Using this approach, four such analogues, including two enantiomeric variants, were synthesized and their antimicrobial activities and hydrolytic stabilities evaluated.

Graphical abstract: A combined solid- and solution-phase approach provides convenient access to analogues of the calcium-dependent lipopeptide antibiotics

Supplementary files

Article information

Article type
Paper
Submitted
11 Nov 2013
Accepted
10 Dec 2013
First published
10 Dec 2013

Org. Biomol. Chem., 2014,12, 913-918

Author version available

A combined solid- and solution-phase approach provides convenient access to analogues of the calcium-dependent lipopeptide antibiotics

P. '. Hart, L. H. J. Kleijn, G. de Bruin, S. F. Oppedijk, J. Kemmink and N. I. Martin, Org. Biomol. Chem., 2014, 12, 913 DOI: 10.1039/C3OB42238K

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