Lewis base catalyzed asymmetric substitution/Diels–Alder cascade reaction: a rapid and efficient construction of enantioenriched diverse tricyclic heterocycles†
Abstract
The first tertiary amine catalyzed asymmetric allylic amination/cycloaddition cascade sequence has been developed, which provided a novel protocol to construct enantioenriched azapolyheterocycles under mild reaction conditions efficiently (up to 95% ee, endo/exo >20 : 1).