Issue 3, 2013
From the journal:

Organic & Biomolecular Chemistry

Synthesis and cytotoxicity of (+/−)-7,9-dideoxy-pancratistatin analogues†

Olaia Nieto-García‡a  and  Ricardo Alonso*a  

* Corresponding authors

a Department of Organic Chemistry, University of Santiago de Compostela, Campus Vida, Santiago de Compostela, Spain
E-mail: r.alonso@usc.es
Fax: +34 981 595012
Tel: +34 981 563100 Ext 14250

Abstract

Access to some 7,9-dideoxy analogues of pancratistatin was achieved by combining our previously reported nitroenal/dioxanone annulation (to form ring C) with a hetero-Diels–Alder/aromatization path to build the dihydroisoquinolinone subunit (rings A and B); testing of their antiproliferative activity afforded some clues about the role of aromatic substituents in pancratistatin's pharmacophore.

Graphical abstract: Synthesis and cytotoxicity of (+/−)-7,9-dideoxy-pancratistatin analogues

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Article information

DOI
https://doi.org/10.1039/C2OB27127C
Article type
Paper
Submitted
31 Oct 2012
Accepted
21 Nov 2012
First published
23 Nov 2012

Org. Biomol. Chem., 2013,11, 515-522

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Synthesis and cytotoxicity of (+/−)-7,9-dideoxy-pancratistatin analogues

O. Nieto-García and R. Alonso, Org. Biomol. Chem., 2013, 11, 515 DOI: 10.1039/C2OB27127C

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