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Issue 5, 2013
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Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes

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Abstract

Oxabenzonorbornadienes were found to be suitable substrates for asymmetric hydroalkynylation reactions. Catalyzed by the complex of [Ir(COD)Cl]2 and (R)-SYNPHOS, oxabenzonorbornadienes and terminal alkynes could react smoothly to give the alkynylated products in moderate to good yields (up to 93% yield) and enantioselectivities (up to 85% ee).

Graphical abstract: Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes

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Article information


Submitted
10 Sep 2012
Accepted
13 Nov 2012
First published
13 Nov 2012

Org. Biomol. Chem., 2013,11, 814-820
Article type
Paper

Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes

J. Hu, Q. Yang, J. Xu, C. Huang, B. Fan, J. Wang, C. Lin, Z. Bian and A. S. C. Chan, Org. Biomol. Chem., 2013, 11, 814
DOI: 10.1039/C2OB26775F

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